CorFlow Presents Fundamental New Insights into the Coronary Microcirculation at the American College of Cardiology (ACC)

Baar, Switzerland, February 22nd 2018

CorFlow Therapeutics AG today announced that the company will present fundamental new insights into the coronary microcirculation during the annual meeting of the American College of Cardiology (ACC) in Orlando, FL, March 10-12, 2018.

CorFlow has since its foundation in June 2016 worked to document that the Controlled Flow Infusion (CoFITM) technology is able to measure the coronary microvascular status and provide therapy to the compromised coronary microcirculation at the same time. Microvascular obstruction (MVO) affects more than half of the acute heart attack patients and is an independent predictor for complications including heart failure which constitutes a high cost burden for the world-wide health care system. To address this large unmet medical need in interventional cardiology, CorFlow has developed an in-vivo model which reproducibly creates MVO in an occlusion-reperfusion model with very low complication rates. Using this in-vivo model, the CoFITM technology was used to measure real-time dynamic microvascular resistance (dMVR) in the coronary circulation and these dMVR values were correlated to post-procedure contrast enhanced magnetic resonance imaging (MRI) and histology. A correlation between the procedural CoFITM dMVR values and post-procedural MRI will enable treatment of MVO before the patients leave the cathlab and potentially reduce the complication rates for severe heart attack patients.

In a comment, Dr. Renu Virmani, an internationally renowned cardiovascular pathologist and co-author of the histology poster, stated: “These findings suggest that the fundamental effects of a human heart attack have to be reconsidered. Our findings show that MVO in acute heart attacks can be created without the presence of thrombi. The results furthermore show that minute reductions in coronary volume flow causes an exponential collapse of the coronary microcirculation and that epicardial revascularization alone is not sufficient to open the collapsed coronary microcirculation. If these findings hold true in our upcoming investigations, we will have to fundamentally rethink the comprehensive treatment of an acute heart attack with attention to the microvasculature as well as the major epicardial vessels.”

(ARTORG), the University Hospital of Zürich (Dept. of Cardiology and Div. of Surgical Research), the University of Zürich (Institute of Veterinary Pathology), NTB/Interstate University of Applied Science Buchs and the Swiss Federal Institutes of Technology (ETH) in Zürich, Switzerland.

The two posters “Controlled Coronary Flow Infusion Measures Myocardial Microvascular Resistance in Real Time During Experimental ST-Elevation Myocardial Infarction” and the histology poster “ST-Elevation Myocardial Infarction-Derived Coronary Microvascular Obstruction Is NOT Thrombus Dependent: Results in a Coronary Model” describe the findings from the CorFlow in-vivo model. The posters will be presented on March 10th (Session 1156) and March 11th (Session 1213) respectively.

Jon H. Hoem, CorFlow’s CEO and co-Founder, commented: “We are very pleased that our in-vivo results have been accepted for publication during the important ACC conference and look forward to discuss these results with cardiologists attending the conference.”

The data from the CorFlow non-clinical trials will be used in the upcoming submissions for the CorFlow MOCA I (MVO with CoFI™ System Assessment I) First-in-Man clinical trial.

The American College of Cardiology (ACC) mission is to transform cardiovascular care and improve heart care. ACC seeks to reach this mission through its members so that they may dramatically reduce the incidence, severity, and complications of cardio-vascular disease through promoting prevention, reduction of disparities in health care and improve personal population-based cardiovascular health.

ACC publishes several well recognised peer-reviewed journals (JACC) with a wide distribution in the inter-ventional cardiology community.

The 67th annual meeting of ACC will this year be held in Orlando, Florida. Last year’s event was attended by 18,300 attendees from 137 countries and hosted 280 exhibitors.

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